IUCLID latest update, 07.11.2023

ECHA has recently released a comprehensive IUCLID dataset comprising 528 approved pharmaceuticals, showcasing information gathered from both animal studies and human data. This addition to the dataset marks a significant step forward in supporting the development of alternatives to traditional animal testing.

This update involves the inclusion of data on 180 new substances, complementing the existing 348 substances added earlier this year. This expanded dataset offers valuable toxicological insights from both animal and human studies in a structured, user-friendly format. Its primary goal is to assist the industry and research community in assessing the toxicity of chemically related compounds, ultimately contributing to the reduction of animal testing. Additionally, this data can be harnessed for the creation of predictive models and for comparing animal and human data.

These IUCLID dossiers were built by extracting data from documents provided by the United States’ Food and Drug Administration. They include studies covering carcinogenicity, as well as the effects of repeated doses, developmental and reproductive toxicity. Furthermore, the dataset contains information on the impact of medicines on humans, sourced from standard product labels of approved pharmaceuticals. For a deep dive into the updates and to download the new archive, click here.

To complement this dataset, ECHA has introduced a specialized ontology, essentially a dictionary of standardized toxicological terms. This tool aids users in classifying and organizing the effects of various chemicals in a consistent manner. The ontology incorporates revisions, updates, and new terms, combining the Ontology Lookup Service’s human and mammalian ontologies, totaling over 20,000 new standardized terms.

ECHA published  a scientific paper explaining the development of this database and ontology, that can be found by clicking here. A follow-up paper will provide an in-depth exploration of the dataset’s scope, contents, and potential applications.

This valuable resource is set to drive progress in the field of toxicology and the reduction of animal testing practices.




Article Issued by Chiara Gazerro