Latest update on cytokines and their subset chemokines

Cytokines and chemokines play a crucial role in safeguarding the body against external threats and diseases. Together, they orchestrate immune responses, regulate immune cell movement, and shape the organization of immune organs. Any disruption or imbalance in these signaling molecules can lead to a spectrum of immune-related diseases.

Leveraging cytokines and antibodies targeting them or their receptors has shown promise in treating autoimmune conditions and certain cancers. In this article, we delve into innovative therapies for advanced malignancies through immunotherapy, including the off-label use of a monoclonal antibody against the interleukin-6 receptor in the treatment of acute respiratory distress syndrome triggered by COVID-19 infection.

Article issued by Carla Landolfi

Full paper ref: Landolfi C. Latest update on cytokines and their subset chemokines. Arch Clin Toxicol. 2020; 2(1): 10-12.

Picture: N Engl J Med 1998; 338:436-445

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